Bispecific Antibody Architecture and TNFRSF Target Selection Determine CD8+ T Cell Differentiation and Anti-tumour Immunity
Marcus A. Widdess, Lucy Wilkinson, Hannah J. Metcalfe, Anastasia Pakidi, HT Claude Chan, Jinny Kim, Tatyana Inzhelevskaya, Anna H. Turaj, Sean H. Lim, Stephen M. Thirdborough, Stephen A. Beers, Mark Steven Cragg, Aymen Al‐Shamkhani
This study shows that bispecific antibody architecture and TNFRSF target selection influence CD8+ T cell differentiation and anti-tumour immunity, with 4-1BB being the most effective target.
bioRxiv · Jun 24, 2026 · PreprintImmunology