Sean H. Lim

This paper evaluates two TNFR2-targeting antibodies, showing ligand-blocking antibodies deplete T regs and reprogram myeloid cells, while agonists directly co-stimulate T and NK cells, both leading to anti-tumor effects.

This study shows that bispecific antibody architecture and TNFRSF target selection influence CD8+ T cell differentiation and anti-tumour immunity, with 4-1BB being the most effective target.

The paper uses single-cell RNA sequencing to identify changes in endometrial cell populations and their interactions in women with recurrent pregnancy loss, linking these changes to altered cellular communication and potential mechanisms of implantation failure.