Synaptophysin is a β-Amyloid Target that Regulates Synaptic Plasticity and Seizure Susceptibility in an Alzhiemer’s Model
Daniel J. Adams, Chong Shen, Josien Levenga, Tamara Basta, Stephen P. Eisenberg, James Mapes, Lukas Hampton, Kelly M. Grounds, Charles A. Hoeffer, Michael H. B. Stowell
This study shows that Aβ42 binds to synaptophysin, disrupting its function and leading to impaired neurotransmission and increased seizure susceptibility in an Alzheimer’s model.
bioRxiv · Apr 25, 2017 · PreprintNeuroscience