Author

James Mapes

University of Colorado Boulder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Angela M. BardoiD· 2 shared Christopher Martin· 2 shared Edward M. MarcotteiD· 2 shared Heather D. StoutiD· 2 shared Thomas Blom· 2 shared Tucker M. FolsomiD· 2 shared Casey J. Howdieshell· 1 shared Charles A. HoefferiD· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

Angela M. BardoORCID

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Author profile →

3 papers

Recent·Most cited

Robust and scalable single-molecule protein sequencing with fluorosequencing

James Mapes, Julia Stover, Heather D. Stout, Tucker M. Folsom, Emily Babcock, Sandra Loudwig, Christopher Martin, Mariah J. Austin, Fan Tu, Casey J. Howdieshell, Zachary Booth Simpson, Thomas Blom, Daniel C. Weaver, Daniel Winkler, Kent Vander Velden, , Jagannath Swaminathan

This paper improves fluorosequencing by optimizing fluorophores, reducing dye interactions, and creating an end-to-end workflow, demonstrating its potential for high-sensitivity clinical proteomics.

bioRxiv · Sep 15, 2023 · PreprintMolecular Biology

Estimating error rates for single molecule protein sequencing experiments

Matthew Beauregard Smith, Kent VanderVelden, Thomas Blom, Heather D. Stout, James Mapes, Tucker M. Folsom, Christopher Martin, Angela M. Bardo, Edward M. Marcotte

The paper develops and compares two methods to estimate error rates in single molecule protein sequencing experiments, finding that one method outperforms the other in most criteria.

bioRxiv · Jul 18, 2023 · PreprintBioinformatics

Synaptophysin is a β-Amyloid Target that Regulates Synaptic Plasticity and Seizure Susceptibility in an Alzhiemer’s Model

Daniel J. Adams, Chong Shen, Josien Levenga, Tamara Basta, Stephen P. Eisenberg, James Mapes, Lukas Hampton, Kelly M. Grounds, Charles A. Hoeffer, Michael H. B. Stowell

This study shows that Aβ42 binds to synaptophysin, disrupting its function and leading to impaired neurotransmission and increased seizure susceptibility in an Alzheimer’s model.

bioRxiv · Apr 25, 2017 · PreprintNeuroscience