Charles A. Hoeffer

This study shows that acute nicotine exposure induces a spatially organized transcriptional response in mouse olfactory cortex, affecting specific neurons and their surrounding astrocytes.

This study identifies Synaptotagmin-2 and Synaptotagmin-3 as distinct calcium sensors for glutamatergic and GABAergic release in lateral habenula neurons.

The paper investigates the role of AKT2 in astrocytic nicotine responses, showing it modulates morphological changes and nicotine preference in mice.

This study shows that polyserine peptides are toxic and worsen tau pathology in mice, supporting their role in human tauopathies.

This study characterizes human induced pluripotent stem cell-derived neurons co-cultured with astrocytes using MEAs, achieving strong network synchrony in six weeks.

This paper develops a nanoligomer-based therapy to treat neuroinflammation by targeting key inflammatory pathways, showing effectiveness in a mouse model.

This study introduces a method to analyze gene-gene interactions across multiple traits and tissues, identifying novel associations and pathways through transcriptome-wide interaction studies.

The paper tests whether genes identified in mouse anxiety models are associated with human anxiety disorders using genome-wide association studies.

The paper assesses the association of two gene sets with smoking behaviors using GWAS data and finds they contribute little to the heritability of these traits.

This study shows that Aβ42 binds to synaptophysin, disrupting its function and leading to impaired neurotransmission and increased seizure susceptibility in an Alzheimer’s model.