Author

Lukas Oldenburg

Brigham and Women's HospitalPrimary ORCID profile (0009-0008-2395-1091 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Lukas OldenburgiD1 paper

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Andrew H. SongiD· 2 shared Drew F. K. WilliamsoniD· 2 shared Faisal MahmoodiD· 2 shared Guillaume JaumeiD· 2 shared Long P. LeiD· 2 shared Richard J. CheniD· 2 shared Rowland W. PettitiD· 2 shared Simone de BrotiD· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBioinformatics

Andrew H. SongORCID

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Author profile →

2 papers

Recent·Most cited

Deep Learning-based Modeling for Preclinical Drug Safety Assessment

Guillaume Jaume, Simone de Brot, Andrew H. Song, Drew F. K. Williamson, Lukas Oldenburg, Andrew Zhang, Richard J. Chen, Javier Asín, Sohvi Blatter, Martina Dettwiler, Christine Goepfert, Llorenç Grau‐Roma, Sara Soto, Stefan M. Keller, Sven Rottenberg, , Faisal Mahmood

This paper introduces TRACE, a deep learning model for automated liver histopathology assessment in preclinical drug safety, achieving higher concordance than pathologists in lesion scoring and dose-response analysis.

bioRxiv · Jul 20, 2024 · PreprintBioinformatics

AI-driven Discovery of Morphomolecular Signatures in Toxicology

Guillaume Jaume, Thomas Peeters, Andrew H. Song, Rowland W. Pettit, Drew F. K. Williamson, Lukas Oldenburg, Anurag Jayant Vaidya, Simone de Brot, Richard J. Chen, Jean‐Philippe Thiran, Long P. Le, Georg Kurt Gerber, Faisal Mahmood

This paper introduces GEESE, an AI model that imputes morphomolecular signatures in toxicology data, linking gene expression changes to drug-induced liver injuries.

bioRxiv · Jul 19, 2024 · PreprintBioinformatics