Simone de Brot

The paper identifies Aurora kinase A as a synthetic lethal target in FANCA-deficient cancers and shows AURKA inhibition induces chromosomal instability and G2/M arrest in these cells.

The paper uses a forward genetic screen in a mouse model to identify Sirtuin1 as a driver of neuroendocrine prostate cancer, showing its role in promoting NEPC and potential as a therapeutic target.

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

This study shows that targeting the minor spliceosome, specifically U6atac snRNA, disrupts DNA repair and overcomes therapy resistance in prostate and breast cancers.

AnnotateAnyCell reduces annotation time for histopathological images by 25% using a semi-supervised framework with active contrastive learning and human-in-the-loop feedback.

This study identifies TAOK1 as a regulator of replication fork stability in BRCA1/2-deficient tumors, showing it enhances sensitivity to PARPi and IR through PCNA and ISG15 interactions.

The paper shows that loss of PI5P4K slows cancer progression in prostate basal cells by disrupting lipid metabolism in a Pten mutant model.

This paper introduces TRACE, a deep learning model for automated liver histopathology assessment in preclinical drug safety, achieving higher concordance than pathologists in lesion scoring and dose-response analysis.

This paper introduces GEESE, an AI model that imputes morphomolecular signatures in toxicology data, linking gene expression changes to drug-induced liver injuries.

This study shows that inhibiting NMD reduces tumorigenicity in HT1080 fibrosarcoma cells by lowering MMP9 expression, suggesting NMD inhibition as a potential cancer therapy.