HPL-2/HP1 and MET-2/SETDB1 bind distinct co-factors that promote heterochromatic foci, gene repression and organogenesis independently of H3K9 methylation
Colin E. Delaney, Lisa Fol, Jia Emil You, Stefan B. Gruenewald, Eugenio Ferrario, Susan M. Gasser, Martin M. Moeckel, Lukas Stelzl, Jan Padeken, Susan E. Mango
The paper shows HPL-2 and MET-2 function in parallel H3K9me-independent pathways for gene repression and organogenesis, using distinct co-factors.
bioRxiv · Sep 29, 2024 · PreprintMolecular Biology