Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells
Janina Müller, Mirna Barsoum, Philip Bussmann, Mohamed H. Elsafi Mabrouk, Roksaneh Sayadi-Boroujeni, Anna-Maria Vllaho, Alexander T. Stenzel, Lukas Vogt, Paul Kießling, Christoph Kuppe, Juliane Lüscher‐Firzlaff, Bernhard Lüscher
The paper shows that reversing PROTAC-induced ASH2L degradation restores H3K4me3, gene expression, and proliferation in senescent cells.
bioRxiv · May 4, 2026 · PreprintCell Biology