Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.
Jun-Ping Bai, Micheal C. Stankewich, Jie Yang, Winston J. T. Tan, Zhongyuan Zuo, Qiang Song, Saaim Khan, Lula Wang, Jon S. Morrow, Joseph Santos‐Sacchi, Dhasakumar S. Navaratnam
This study shows that knocking out alpha2 spectrin in postnatal outer hair cells leads to a dissociation of prestin's gating charge movement from electromotility and structural changes in the SSC and plasma membrane-SSC space.
Journal of Biological Chemistry · Feb 3, 2026Peer-reviewedPhysiology