Lymphatic Malformations with Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases
Diandra M. Mastrogiacomo, Abbigail Price, Yuting Fu, Richa Banerjee, Luz A. Knauer, Kunyu Li, Ying Yang, George E. Davis, Michael T. Dellinger, Joshua Paul Scallan
This study shows that KRAS mutations impair lymphatic valve development by upregulating MMPs, which degrade the valve ECM core.
Arteriosclerosis Thrombosis and Vascular Biology · Mar 26, 2026Peer-reviewedPathology