PathologyArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewed
Lymphatic Malformations with Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases
Diandra M. Mastrogiacomo, Abbigail Price, Yuting Fu…·Joshua Paul Scallan
This study shows that KRAS mutations impair lymphatic valve development by upregulating MMPs, which degrade the valve ECM core.
DOI 10.1161/atvbaha.126.324257