Taccalonolide AJ uncouples tubulin GTP hydrolysis from microtubule depolymerization
Ezekiel C. Thomas, Nicholas E. Vangos, Lauren A McCormick, Lynne Blasius, Kristen J. Verhey, April L. Risinger, Michael A. Cianfrocco
This study shows that taccalonolide AJ stabilizes microtubules through a mechanism distinct from paclitaxel, promoting a compacted, post-GTP hydrolysis state that resists depolymerization.
bioRxiv · Oct 2, 2026 · PreprintBiochemistry