David Sept

The paper investigates how tubulin C-terminal tails respond to pH changes and shows their role in regulating microtubule interactions through protonation of glutamate residues.

This study identifies structural switches in tubulin that Taxol exploits to stabilize microtubules by reverting them to a pre-hydrolysis state.

The paper investigates the accessibility of the α-tubulin C-terminal tail (Y-CTT) and finds it is regulated by microtubule lattice conformation through nucleotide state and MAP interactions.

This study compares the conformational flexibility of Drosophila and bovine tubulins and links it to differences in microtubule dynamic instability.

The paper demonstrates that motor clustering enhances kinesin-driven vesicle transport efficiency, reducing the required number of motors for long-distance transport.

The paper shows that most actin subunits in lamellipodial networks come from membrane-associated polymerases, not directly from solution.