Oncogenic GNAQ/11-induced remodeling of the IP3/Calcium signaling pathway protects Uveal Melanoma against Calcium-driven cell death
Garcia Céline, Roussel Louis, M Sarah, Laura Brard, Rita Maria Laura La Rovere, Sophie Tartare‐Deckert, Corine Bertolotto, Geert Bultynck, Sabrina Leverrier, Aubin Penna
This study shows that GNAQ/11 mutations in uveal melanoma alter IP3 receptor expression, protecting cells from calcium-driven death while promoting proliferation.
bioRxiv · Nov 25, 2024 · PreprintCancer Biology