This study shows that lipid nanoparticles can activate TRPA1 through multiple calcium influx mechanisms, suggesting a new non-canonical activation pathway.

bioRxiv · May 5, 2026 · PreprintPharmacology & Toxicology

IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta

Marjo K. Hytönen, Julius Rönkkö, Sruthi Hundi, Tarja Susanna Jokinen, Emilia Suonto, Eeva Teräväinen, Jonas Donner, Rita La Rovere, Geert Bultynck, Emil Ylikallio, Henna Tyynismaa, Hannes Lohi

This paper identifies a homozygous nonsense variant in ITPR3 in Lancashire Heeler dogs causing enamel defects and nerve dysfunction, showing IP3R3 loss affects IP3R1 and IP3R2 levels and Ca2+ signaling.

PLoS Genetics · Jan 13, 2025Peer-reviewedGenetics

Oncogenic GNAQ/11-induced remodeling of the IP3/Calcium signaling pathway protects Uveal Melanoma against Calcium-driven cell death

Garcia Céline, Roussel Louis, M Sarah, Laura Brard, Rita Maria Laura La Rovere, Sophie Tartare‐Deckert, Corine Bertolotto, Geert Bultynck, Sabrina Leverrier, Aubin Penna

This study shows that GNAQ/11 mutations in uveal melanoma alter IP3 receptor expression, protecting cells from calcium-driven death while promoting proliferation.

bioRxiv · Nov 25, 2024 · PreprintCancer Biology

A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome

K. Ahuja, Marjan Vandenabeele, Fatemeharefeh Nami, Evy Lefevere, J. Van hoecke, Steven Bergmans, Marie Claes, Tim Vervliet, Katrien Neyrinck, T. Burg, D. De Herdt, P. Bhaskar, Y. Zhu, Zoe J. Looser, Jens Loncke, , Lies De Groef

This study investigates the role of oligodendroglia in Wolfram syndrome using mouse models and iPSC-derived cells, finding preserved oligodendroglia function and suggesting alternative targets for treatment.

Acta Neuropathologica Communications · Aug 28, 2024Peer-reviewedNeuroscience