Benoît Le Tallec

High-resolution single-molecule replication profiling of the human genome

The paper develops a method to create high-resolution single-molecule replication maps of the human genome using multipulse BrdU labelling and ForkML.

A Closed-Form Bayesian Model for DNA Replication Reveals Intrinsic Origin Timing and Activation Delays

This paper introduces a Bayesian model for DNA replication that infers origin timing and activation delays using RFD data, revealing 150 origins with significant delays in yeast.

Nanotiming: telomere-to-telomere DNA replication timing profiling by nanopore sequencing

Nanotiming provides high-resolution telomere-to-telomere replication timing profiles using nanopore sequencing, validated in yeast with cost and simplicity advantages.

FORK-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing

FORK-seq maps DNA replication at single-molecule resolution in yeast, revealing previously missed initiation and termination events.

Transcription-dependent regulation of replication dynamics modulates genome stability

The paper investigates how transcription affects replication dynamics and genome stability in large genes, finding that moderate transcription increases instability while high transcription reduces it.

Mapping DNA replication with nanopore sequencing

The paper uses nanopore sequencing and a neural network to identify BrdU-labelled DNA tracts in yeast during replication, showing they align with early-firing origins.