MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4 γ- dependent transcription of CES enzymes
R. Datta, M. A. Gholampour, C. D. Yang, R. Volk, S. Lin, M. J. Podolsky, T. Arnold, F. Rieder, B. W. Zaro, M. Verzi, R. Lehner, N. Abumrad, C. O. Lizama, K. Atabai
This study identifies CES1D as the hydrolase downstream of the MFGE8-vβ5 integrin pathway that regulates catabolism of diet-derived lipid droplets in enterocytes.
bioRxiv · May 16, 2022Physiology