Author

R. Lehner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

R. Watts· 2 shared B. W. Zaro· 1 shared C. D. Yang· 1 shared C. Nikain· 1 shared C. O. Lizama· 1 shared E. A. Fisher· 1 shared F. Rieder· 1 shared H. Wang· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

R. Watts

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

H. Wang, C. Nikain, J. Amengual, M. La Forest, Y. Yu, M. C. Wang, R. Watts, R. Lehner, Y. Qiu, M. Cai, I. J. Kurland, I. J. Goldberg, S. Rajan, M. M. Hussain, J. L. Brodsky, E. A. Fisher

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

bioRxiv · Dec 5, 2023 · PreprintBiochemistry

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4 γ- dependent transcription of CES enzymes

R. Datta, M. A. Gholampour, C. D. Yang, R. Volk, S. Lin, M. J. Podolsky, T. Arnold, F. Rieder, B. W. Zaro, M. Verzi, R. Lehner, N. Abumrad, C. O. Lizama, K. Atabai

This study identifies CES1D as the hydrolase downstream of the MFGE8-vβ5 integrin pathway that regulates catabolism of diet-derived lipid droplets in enterocytes.

bioRxiv · May 16, 2022Physiology

Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes

R. Selvaraj, S. V. Zehnder, R. Watts, J. Lian, R. Nelson, R. Lehner

The paper investigates the preferential lipolysis of triacylglycerol (TG) generated by DGAT1 versus DGAT2 in Huh7 hepatocytes, finding that DGAT1-TG is preferentially targeted for fatty acid oxidation.

bioRxiv · Jun 18, 2021Cell Biology