R. Datta

In vivo changes in zebrafish anesthetic sensitivity in response to the loss of kif5Aa are associated with the alteration of mitochondrial motility

This study shows that loss of kif5Aa in zebrafish alters anesthetic sensitivity and mitochondrial motility in response to propofol, etomidate, and dexmedetomidine.

Syntaxin-2 coordinates endolysosomal trafficking to balance phagocytic uptake and phagolysosomal clearance in macrophages

This study identifies syntaxin-2 as a regulator of phagocytic uptake and phagolysosomal clearance in macrophages by coordinating receptor density, cup expansion, and maturation.

Naive primary neutrophils play a dual role in the tumor microenvironment

This study investigates the dual role of naive primary neutrophils in the tumor microenvironment, showing they both restrict tumor invasion and hinder NK cell penetration through ROS and NETs.

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

MFGE8 inhibits insulin signaling through PTP1B

This study shows MFGE8 inhibits insulin signaling by promoting PTP1B binding to and dephosphorylation of IR{beta}, reducing glucose uptake, and identifies a correlation between serum MFGE8 levels and insulin resistance in humans.

Designer grass pea for transgene-free minimal neurotoxin-containing seeds with CRISPR-Cas9

This study uses CRISPR-Cas9 to create grass pea plants with minimal neurotoxin {beta}-ODAP in seeds, achieving 99% reduction without transgenes.

A novel role of macrophage PIST protein in regulating Leishmania major infection

This study shows that macrophage PIST protein regulates Leishmania major infection by interacting with Beclin 1 and affecting parasite replication.

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

The paper identifies SEL1L as a regulator of collagen turnover through a negative feedback loop, showing its role in limiting collagen accumulation in fibrotic lung disease.

Glutathione-mediated S-Nitrosylation of WRKY75 modulates PHT1;5 expression to orchestrate phosphate homeostasis in Arabidopsis

The paper shows that glutathione-mediated S-nitrosylation of WRKY75 activates AtPHT1;5 to regulate phosphate homeostasis in Arabidopsis under phosphate starvation.

Localized Leishmania major infection causes systemic iron deficiency that can be controlled by oral iron supplementation

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4 γ- dependent transcription of CES enzymes

This study identifies CES1D as the hydrolase downstream of the MFGE8-vβ5 integrin pathway that regulates catabolism of diet-derived lipid droplets in enterocytes.

Adipose deficiency and aberrant autophagy in a Drosophila model of MPS VII is corrected by pharmacological stimulators of mTOR

This study identifies autophagy dysfunction and mTOR downregulation as causes of adipose deficiency in a Drosophila model of MPS VII, showing that mTOR stimulators can reverse these defects.

Glutathione regulates transcriptional activation of iron transporters via S-nitrosylation of bHLH factors to modulate subcellular iron homeostasis

This study shows glutathione regulates subcellular iron homeostasis under iron deficiency by activating iron transporters through S-nitrosylation of bHLH transcription factors.

Leishmania major formins are cytosolic actin bundler play an important role in cell physiology

This study identifies and characterizes two formins in Leishmania major, showing they bind and bundle actin, and are essential for parasite growth and morphology.

The novel leishmanial Copper P-type ATPase plays a vital role in intracellular parasite survival

This study identifies and characterizes the Leishmania major Cu-ATPase, LmATP7, and demonstrates its role in copper stress resistance and parasite survival within macrophages.

Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors

The paper investigates how interactions with pancreatic stromal cells affect the redox state of cancer cells, finding that these interactions promote a more oxidized redox state in cancer cells.

Functional partnership between carbonic anhydrase and malic enzyme in promoting gluconeogenesis in Leishmania major

This study identifies a functional partnership between carbonic anhydrase and malic enzyme in Leishmania major that compensates for the absence of pyruvate carboxylase in gluconeogenesis.

Osr40g3 imparts salt tolerance by regulating GF14e-mediated gibberellin metabolism to activate EG45 in rice

This study identifies Osr40g3 as a gene that enhances salt tolerance in rice by regulating gibberellin metabolism through interactions with OsGF14e and OsEG45.

Jacalin domain-containing protein OsSalT interacts with OsDREB2A and OsNAC1 to impart drought stress tolerance in planta

Rice lectin protein Osr40c1 imparts drought tolerance by modulating OsSAM2, OsSAP8 and chromatin-associated proteins

This study identifies Osr40c1 as a rice lectin protein that enhances drought tolerance by modulating OsSAM2, OsSAP8, OsMNB1B, and OsH4, which regulate downstream gene expression and polyamine biosynthesis.

Leishmania infection triggers hepcidin-mediated proteasomal degradation of Nramp1 resulting in increased phagolysosomal iron availability

This study shows that Leishmania infection causes hepcidin-mediated proteasomal degradation of Nramp1, increasing phagolysosomal iron availability and promoting parasite growth.