Loss of KRASG12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer
L. Wan, K.-T. Lin, M. A. Rahman, Z. Wang, M. A. Jensen, Y. Park, D. A. Tuveson, A. R. Krainer
The paper shows that loss of SRSF1, a splicing factor, accelerates pancreatic cancer by disrupting homeostasis and enhancing KrasG12D-driven tumorigenesis.
bioRxiv · Oct 13, 2021 · PreprintCancer Biology