Author

A. R. Krainer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. M. McCandlish· 2 shared J. B. Kinney· 2 shared K.-T. Lin· 2 shared M. S. Wong· 2 shared A. Ayaz· 1 shared A. Geier· 1 shared A. K. Kesarwani· 1 shared C. Hu· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

D. M. McCandlish

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Author profile →

4 papers

Recent·Most cited

Specificity, synergy, and mechanisms of splice-modifying drugs

Y. Ishigami, M. S. Wong, C. Marti-Gomez, A. Ayaz, M. Kooshkbaghi, S. Hanson, D. M. McCandlish, A. R. Krainer, J. B. Kinney

This study develops quantitative models to understand how splice-modifying drugs work, showing drug-specific mechanisms and revealing widespread drug synergy and cooperativity.

bioRxiv · Dec 30, 2022Biophysics

Loss of KRASG12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer

L. Wan, K.-T. Lin, M. A. Rahman, Z. Wang, M. A. Jensen, Y. Park, D. A. Tuveson, A. R. Krainer

The paper shows that loss of SRSF1, a splicing factor, accelerates pancreatic cancer by disrupting homeostasis and enhancing KrasG12D-driven tumorigenesis.

bioRxiv · Oct 13, 2021 · PreprintCancer Biology

Higher-order epistasis and phenotypic prediction

J. Zhou, M. S. Wong, W.-C. Chen, A. R. Krainer, J. B. Kinney, D. M. McCandlish

This paper introduces a method to model higher-order genetic interactions from partially observed data and applies it to predict phenotypes in antibody-binding domains and splicing efficiency.

bioRxiv · Oct 14, 2020Evolutionary Biology

Differential functions of splicing factors in breast-cancer initiation and metastasis

S. Das, M. Akerman, S. Park, M. Brugioli, A. Geier, A. K. Kesarwani, M. Fan, N. Leclair, L. Urbanski, K.-T. Lin, C. Hu, X. Hua, J. George, S. K. Muthuswamy, A. R. Krainer, O. Anczukow

This study identifies splicing factors involved in breast cancer initiation and metastasis, showing their differential roles and interactions with MYC.

bioRxiv · May 10, 2019Cancer Biology