Author

D. A. Tuveson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 6 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

Y. Park· 3 shared C. R. Vakoc· 2 shared C. Tonelli· 2 shared D. J. Pappin· 2 shared D. Plenker· 2 shared G. Biffi· 2 shared K. D. Rivera· 2 shared L. Garcia· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

Y. Park

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9 papers

Recent·Most cited

MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer

O. Klingbeil, D. Skopelitis, C. Tonelli, A. Alpsoy, F. Minicozzi, D. Aggarwal, S. Russo, T. Ha, O. E. Demerdash, D. L. Spector, D. A. Tuveson, P. Cifani, C. R. Vakoc

This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.

bioRxiv · Feb 26, 2024Cancer Biology

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma

S. K. Hur, T. D. D. Somerville, X. S. Wu, D. Maia-Silva, O. E. Demerdash, D. A. Tuveson, F. Notta, C. R. Vakoc

This study shows p73 activates basal lineage and ciliogenesis genes in PDAC, suggesting its role in lineage plasticity and tumor progression.

bioRxiv · Apr 20, 2023 · PreprintCancer Biology

Internally-controlled and dynamic optical measures of functional tumor biology

T. Chung, L. Garcia, M. M. Swamynathan, F. E. M. Froeling, L. C. Trotman, D. A. Tuveson, S. K. Lyons

This paper develops internally controlled optical reporters to quantitatively measure functional tumor biology, improving the accuracy of drug response assessment in vitro and in vivo.

bioRxiv · May 30, 2022 · PreprintCancer Biology

Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancer

C. Tonelli, A. Deschenes, M. A. Yao, Y. Park, D. A. Tuveson

bioRxiv · Dec 31, 2021 · PreprintCancer Biology

Loss of KRASG12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer

L. Wan, K.-T. Lin, M. A. Rahman, Z. Wang, M. A. Jensen, Y. Park, D. A. Tuveson, A. R. Krainer

The paper shows that loss of SRSF1, a splicing factor, accelerates pancreatic cancer by disrupting homeostasis and enhancing KrasG12D-driven tumorigenesis.

bioRxiv · Oct 13, 2021 · PreprintCancer Biology

Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer

D. K. Cheng, T. E. Oni, Y. Park, J. S. Thalappillil, H.-c. Ting, N. Prasad, B. Alagesan, K. D. Rivera, D. J. Pappin, L. Van Aelst, D. A. Tuveson

This study identifies RSK1 as a KRASG12D-specific interactor in PDAC and shows RSK1 mediates negative feedback on wild-type KRAS.

bioRxiv · Sep 14, 2020 · PreprintCancer Biology

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS

T. E. Oni, C. Bautista, J. R. Merrill, J. A. C. M. Goos, K. D. Rivera, K. Miyabayashi, G. Biffi, L. Garcia, D. Plenker, H. Patel, E. Elyada, M. Samaritano, K. H. Yu, D. J. Pappin, M. G. Goggins, , D. A. Tuveson

This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.

bioRxiv · Sep 10, 2020 · PreprintCancer Biology

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker

C. Gao, L. Wisniewski, Y. Liu, B. Staal, I. Beddows, D. Plenker, M. Aldakkak, J. Hall, D. Barnett, M. Kheir Gouda, P. Allen, R. Drake, A. Zureikat, Y. Huang, D. Evans, , B. Haab

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

bioRxiv · Jun 1, 2020 · PreprintCancer Biology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology