J. P. Saenz

From hot to cold: dissecting lipidome adaptation in Mycoplasma mycoides and the Minimal Cell JCVI-Syn3B

This study analyzes lipidome adaptation in Mycoplasma mycoides and its minimal cell JCVI-Syn3B under temperature changes, revealing universal patterns and constraints in lipid remodeling.

Varying the position of phospholipid acyl chain unsaturation modulates hopanoid and sterol ordering

This study shows that hopanoids and sterols modulate lipid ordering differently based on phospholipid acyl chain unsaturation position, with cholesterol providing broader ordering effects than diplopterols.

A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress

The paper introduces a method to isolate organellar membranes from yeast and uses it to study lipid composition and stress responses in the endoplasmic reticulum and vacuolar membranes.

Hopanoids confer robustness to physicochemical variability in the niche of the plant symbiont Bradyrhizobium diazoefficiens

This study shows that hopanoids in Bradyrhizobium diazoefficiens provide robustness to environmental variability in soil, explaining discrepancies between in vitro and in planta results.

Lipid membranes modulate the activity of RNA through sequence-dependent interactions

This study shows lipid membranes modulate RNA activity through sequence-dependent interactions, enabling the development of synthetic riboswitches and lipid biosensors.

Functional diversity of isoprenoidal lipids in Methylobacterium extorquens PA1

This study investigates the functional roles of hopanoids and carotenoids in Methylobacterium extorquens PA1, revealing complementary biophysical roles in outer membrane properties and growth.

New method for high-throughput measurements of viscosity in submicrometer-sized membrane systems

The paper develops a high-throughput method to measure microviscosity in lipid membranes using a fluorescent dye and plate reader, validated with artificial membranes and applied to detect phase transitions in Mycoplasma mycoides.

Environmentally induced lipidome adaptation in the bacterial model organism M. extorquens

The paper examines lipidome adaptation in M. extorquens under various environmental stresses and finds that few lipids drive most changes, with temperature having the greatest impact.