Author

M. J. A. Groot Koerkamp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

F. C. P. Holstege· 2 shared J. DeMartino· 2 shared J. Drost· 2 shared L. S. Hiemcke-Jiwa· 2 shared M. Brok· 2 shared M. T. Meister· 2 shared T. de Souza· 2 shared A. Homavar· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

F. C. P. Holstege

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Author profile →

3 papers

Recent·Most cited

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma.

J. DeMartino, M. T. Meister, L. Visser, M. Brok, M. J. A. Groot Koerkamp, L. S. Hiemcke-Jiwa, T. de Souza, J. Merks, F. C. Holstege, T. Margaritis, J. Drost

This study uses single-cell transcriptomics to identify immune suppression and cell states in rhabdomyosarcoma that predict patient outcomes.

bioRxiv · Jul 15, 2022 · PreprintCancer Biology

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

M. T. Meister, M. J. A. Groot Koerkamp, T. de Souza, W. B. Breunis, E. Frazer-Mendelewska, M. Brok, J. DeMartino, F. Manders, C. Calandrini, H. H. D. Kerstens, A. Janse, M. E. M. Dolman, S. Eising, K. P. S. Langenberg, M. van Tuil, , F. C. P. Holstege

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

bioRxiv · Jan 3, 2022Cancer Biology

Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant

X. Bao, M. C. Koorengevel, M. J. A. Groot Koerkamp, A. Homavar, A. Weijn, S. Crielaard, M. F. Renne, W. J. C. Geerts, M. A. Surma, M. Mari, F. C. P. Holstege, C. Klose, A. I. P. M. de Kroon

This study shows that acyl chain shortening via ACC1 inhibition allows yeast to grow without phosphatidylcholine by altering lipid biosynthesis pathways.

bioRxiv · Feb 8, 2021Biochemistry