Tumor Edge-to-Core Transition Promotes Malignancy in Primary-to-Recurrent Glioblastoma Progression in a PLAGL1/CD109-mediated mechanism
C. Li, H. J. Cho, D. Yamashita, M. Abdelrashid, Q. Chen, S. Bastola, G. Chagoya, G. A. Elsayed, S. Komarova, S. Ozaki, Y. Ohtsuka, T. Kunieda, H. I Kornblum, T. Kondo, D.-H. Nam, I. Nakano
The paper identifies a CD133down/CD109up signature associated with poor prognosis in glioblastoma recurrence and shows PLAGL1 mediates tumor progression through CD109 regulation.
bioRxiv · Sep 14, 2020Cancer Biology