S. Bastola

Identification, antimicrobial resistance and molecular detection of Shiga toxin-producing E. coli (STEC) isolated from raw milk of cattle in Chitwan, Nepal

This study identifies and characterizes Shiga toxin-producing E. coli (STEC) in raw cattle milk from Nepal, finding a prevalence of 11.6% and highlighting antimicrobial resistance patterns.

Microenvironmental Stiffness Induces Metabolic Reprogramming in Glioblastoma

This study shows that a softer matrix microenvironment induces glioblastoma cells to shift toward glycolysis, increasing migration and decreasing proliferation.

Generation of a molecular interactome of the glioblastoma perivascular niche reveals Integrin Binding Sialoprotein as a key mediator of tumor cell migration

Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastoma

This study identifies Endocan as an endothelial-secreted ligand for PDGFR alpha that promotes GBM vascularity, radioresistance, and phenotypic diversity.

Brain aging-dependent glioma traits reversible by NAD+/BDNF-mediated neuronal reactivation

This study shows that aging reduces neuronal signaling in gliomas, but NAD+ and BDNF can reverse these effects, improving outcomes in older mice.

Tumor Edge-to-Core Transition Promotes Malignancy in Primary-to-Recurrent Glioblastoma Progression in a PLAGL1/CD109-mediated mechanism

The paper identifies a CD133down/CD109up signature associated with poor prognosis in glioblastoma recurrence and shows PLAGL1 mediates tumor progression through CD109 regulation.

Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion

This study identifies lysine residues critical for BMP2 degradation and shows genetic modifications can enhance its stability and extracellular secretion.