Author

D.-H. Nam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

D. Yamashita· 3 shared I. Nakano· 3 shared H. J. Cho· 2 shared H. Kim· 2 shared J. Wang· 2 shared M. A. Nakano· 2 shared S. Ozaki· 2 shared T. Kondo· 2 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

D. Yamashita

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Native Korean wild mice (Mus musculus): molecular phylogeny and morphometrics

D. Kim, J. Oh, J. G. Oh, H.-Y. Yang, G.-J. Kim, T.-H. Lee, B.-G. Lee, C. Park, D.-H. Nam

The paper analyzes genetic and morphological data of Korean wild mice to determine their phylogenetic relationships and taxonomic status within the Mus musculus subspecies.

bioRxiv · May 6, 2024 · PreprintZoology

High-dose drug heat map based on organoid array chip for drug selection with high safety and efficacy

S.-Y. Lee, Y. Teng, M. Son, B. Ku, H. S. Moon, V. Tergaonkar, P. K.-H. Chow, D. W. Lee, D.-H. Nam

The paper develops an organoid array chip to test drug safety and efficacy using high-dose drug heat maps, identifying four compounds with high efficacy and low toxicity against GBM cells.

bioRxiv · May 11, 2021 · PreprintCancer Biology

Spatiotemporal Dynamics of Intra-tumoral Dependence on NEK2-EZH2 Signaling in Glioblastoma Cancer Progression

J. Wang, M. S. Pavlyukov, D. Yamashita, P. Cheng, Z. Zhang, S.-H. Kim, M. A. Nakano, W. Xie, D. Chen, B. Frett, W.-h. Hu, Y. J. Shin, Y. Lee, V. Goidts, D.-H. Nam, , I. Nakano

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

bioRxiv · Dec 1, 2020 · PreprintCancer Biology

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

D. Yamashita, D. Botta, H. J. Cho, X. Guo, S. Ozaki, V. L. Flanary, I. Sirota, M. Gao, S. Yamaguchi, M. A. Nakano, F. Zhou, H. Zhou, T. Kondo, T. Kunieda, D. Crossman, , I. Nakano

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

bioRxiv · Nov 26, 2020 · PreprintCancer Biology

Tumor Edge-to-Core Transition Promotes Malignancy in Primary-to-Recurrent Glioblastoma Progression in a PLAGL1/CD109-mediated mechanism

C. Li, H. J. Cho, D. Yamashita, M. Abdelrashid, Q. Chen, S. Bastola, G. Chagoya, G. A. Elsayed, S. Komarova, S. Ozaki, Y. Ohtsuka, T. Kunieda, H. I Kornblum, T. Kondo, D.-H. Nam, I. Nakano

The paper identifies a CD133down/CD109up signature associated with poor prognosis in glioblastoma recurrence and shows PLAGL1 mediates tumor progression through CD109 regulation.

bioRxiv · Sep 14, 2020Cancer Biology

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

B. Oldrini, N. Vaquero-Siguero, Q. Mu, P. Kroon, Y. Zhang, M. Galan-Ganga, Z. Bao, Z. Wang, H. Liu, J. K. Sa, J. Zhao, H. Kim, S. Rodriguez-Perales, D.-H. Nam, R. G. Verhaak, , M. Squatrito

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

Nature Communications · Aug 4, 2020Peer-reviewedCancer Biology

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

A. C. deCarvalho, H. Kim, L. M. Poisson, M. E. Winn, C. Mueller, D. Cherba, J. Koeman, S. Seth, A. Protopopov, M. Felicella, S. Zheng, A. Multani, Y. Zhang, J. Zhang, D.-H. Nam, , R. Verhaak

This study shows that extrachromosomal DNA elements and chromosomal alterations in glioblastoma have distinct inheritance patterns and contribute to genomic heterogeneity during tumor evolution.

bioRxiv · Jun 27, 2017Cancer Biology