Nutrient excess remodels islet autonomic innervation via pancreatic schwann cells
Rollie F. Hampton, Maria Jiménez-González, Rui Kang, Alexandra Alvarsson, D. Espinoza, Jamie R. E. Carty, F. Seibold, Luca Lambertini, Lucia Alexeyev, Rosemary Li, Kavya Devarakonda, Ge Lu, Brianna Agyapong, JESLYN CHOUDHURY, M. Alon, , Sarah A. Stanley
This study shows that nutrient excess remodels pancreatic islet innervation through Schwann cells, impairing glycemic control, and demonstrates that neuromodulation can improve outcomes.
bioRxiv · Jul 1, 2025 · PreprintPhysiology