Author

M. Ashcroft

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:metabolomics· 1

Frequent Co-Authors

C. Esposito· 2 shared J. M. Stephen· 2 shared L. W. Thomas· 2 shared A. Ahmed· 1 shared A. S. Costa· 1 shared C. Frezza· 1 shared G. Szabadkai· 1 shared H. Al-Habib· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

C. Esposito

Mutual co-authors in cluster

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2 papers

Recent·Most cited

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.

L. W. Thomas, J. M. Stephen, C. Esposito, S. Hoer, R. Antrobus, A. Ahmed, H. Al-Habib, M. Ashcroft

This study shows CHCHD4 enhances tumor cell survival by regulating mitochondrial respiratory chain function, making tumor cells more vulnerable to inhibition of complex I.

bioRxiv · Jan 7, 2019Cell Biology

CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolism.

L. W. Thomas, C. Esposito, J. M. Stephen, A. S. Costa, C. Frezza, T. S. Blacker, G. Szabadkai, M. Ashcroft

This study shows CHCHD4 promotes tumour cell proliferation and suppresses EMT through complex I-mediated mitochondrial metabolism.

bioRxiv · Jan 7, 2019 · PreprintCell Biology