A. Ahmed

Endothelial gain of PIEZO/TRPV mechanosensors drives cavernous malformations

This study identifies PIEZO1, TRPV2, and TRPV4 as mechanosensors overexpressed in CCM lesions, showing their role in driving disease through altered adhesion and matrix degradation.

JAK2/STAT3 signaling pathway mediates methylmercury toxicity in mouse astrocyte neuronal C8-D1A cell line

This study investigates the role of the JAK2/STAT3 signaling pathway in mitigating methylmercury toxicity in astrocytes, showing that STAT3 inhibition worsens oxidative stress and cell death.

An in vivo 'turning model' reveals new RanBP9 interactions in lung macrophages.

This paper uses a novel mouse model to identify new RanBP9 interactions in lung macrophages, revealing its role in immune and metabolic functions.

HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA+ plasma cells in the GI tract

Exploring Behavioral and Neural Dynamics of Social Interactions during the Juvenile Stage in a Mouse Model of Fragile X Syndrome

This study examines social behavior and cortical activity in juvenile Fmr1 knockout and heterozygous mice, revealing sex- and genotype-dependent differences in social interactions and oscillatory brain activity.

Unravelling the conundrum of nucleolar NR2F1 localization: A comparative analysis of NR2F1 antibody-based approaches in vitro and in vivo.

The paper investigates NR2F1 nucleolar localization using multiple antibodies in vitro and in vivo, finding it artificial and non-functional, and recommends optimal antibody use.

Preventing evolutionary rescue in cancer

This paper develops a theoretical framework to optimize cancer treatment scheduling by exploiting stochastic extinction of small tumors, showing that switching to a second treatment when the tumor is near its minimum size maximizes eradication probability.

DEVELOPMENT AND EVALUATION OF COATED RICOTTA CHEESE WITH WHEY PROTEIN AND CLOVE OIL

This study evaluates the effect of whey protein and clove oil coatings on ricotta cheese shelf life, finding that 0.75% whey protein and 0.3% clove oil significantly extended shelf life to 21 days.

A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease

This paper develops a 3D microtumour system that mimics ovarian cancer minimal residual disease, showing it responds to chemotherapy and reflects molecular signatures of MRD.

Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment

This study creates 3D collagen matrices with tumor-mimetic fiber alignment gradients to investigate their effect on cell migration.

Confinement by liquid-liquid interface replicates in vivo neutrophil deformations and elicits bleb based migration

This paper introduces a liquid-liquid interface system to model in vivo neutrophil migration, finding that neutrophils use bleb-based force generation to deform barriers under confining pressures.

Socio-demographic determinants of monkeypox virus preventive behavior: a cross-sectional study in Pakistan

This study assesses knowledge, attitudes, and practices of monkeypox virus in Pakistan, finding that gender, education, and income influence preventive behaviors.

eEF2 improves dense connective tissue repair and healing outcome by regulating cellular death, autophagy, apoptosis, proliferation and migration

The paper identifies eEF2 as a prognostic biomarker for dense connective tissue repair outcomes and shows it regulates cellular processes to improve healing.

Immune Contexture of Isocitrate Dehydrogenase stratified Human Gliomas

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

Metabolic costs of walking and arm reaching in persons with mild multiple sclerosis

This study measures metabolic costs of walking and arm reaching in people with mild MS and controls, finding higher walking costs in MS but no reaching cost differences.

Differences in anti-viral immune responses in individuals of Indian and European origin: relevance for the COVID-19 pandemic

The paper compares anti-viral immune responses between individuals of Indian and European origin, finding differences in chromatin accessibility and transcriptional responses to viral stimulation, which may explain variations in COVID-19 susceptibility.

Evidence for the Existence of a Bacterial Etiology for Alzheimers Disease and for a Temporal-Spatial Development of a Pathogenic Microbiome in the Brain

The paper identifies bacterial communities in Alzheimer's Disease and control brains, finding a complex microbiome dynamics associated with AD pathogenesis.

Exploring Taxonomic and Functional Microbiome of Hawaiian Stream and Spring Irrigation Water Systems Using Illumina and Oxford Nanopore Sequencing Platforms

This study analyzes bacterial communities and their functions in irrigation water from Hawaiian farms using Illumina and Oxford Nanopore sequencing, identifying key taxa and antibiotic resistance genes.

A Miniaturized 3D-Printed Pressure Regulator (μPR) for Microfluidic Cell Culture Applications

The paper introduces a 3D-printed micro pressure regulator for microfluidic cell culture, demonstrating tunable pressure control and compatibility with human endothelial cells in continuous flow.

The Modular μSiM Reconfigured: Integration of Microfluidic Capabilities to Study in vitro Barrier Tissue Models under Flow

The paper introduces a reconfigurable microfluidic platform that integrates microfluidic capabilities with conventional open-well systems for studying barrier tissues under flow.

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

The paper examines antibody responses to SARS-CoV-2 variants, finding convergent epitope specificities, V gene usage, and public B cell clones across different variants.

Cell Chromatography: Biocompatible chromatographic separation and interrogation of microbial cells

This paper introduces a biocompatible chromatography method for isolating and analyzing microbial cells, enabling purification and interrogation of single or mixed cultures with high viability.

Local extensional flows promote long-range fiber alignment in 3D collagen hydrogels

The paper demonstrates that local extensional flows align collagen fibers in 3D hydrogels, enabling long-range fiber alignment and multi-layered matrix fabrication.

No One Is Leaving This Time: Appraisal of Awareness and Knowledge of Port Health Officers on International Health Regulation IHR (2005)

The paper assesses awareness and knowledge of IHR (2005) among port health officers and finds that while most are aware, only a minority demonstrate good knowledge.

Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products

This study identifies lytic transglycosylases (LTGs) as essential for preventing periplasmic crowding by degrading peptidoglycan turnover products, independent of peptidoglycan recycling.

ARF4-mediated Retrograde Trafficking Drives Chemoresistance in Glioblastoma

This study identifies ARF4 as a driver of chemoresistance in glioblastoma through a CRISPR screen and shows it mediates retrograde trafficking of EGFR into the nucleus.

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

This study evaluates an adjuvanted SARS-CoV-2 RBD nanoparticle vaccine in macaques, showing robust immune responses and protection against viral challenge and variants.

Efficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Primates

A SARS-CoV-2 Spike ferritin nanoparticle vaccine induces broad neutralizing antibodies and protects nonhuman primates against respiratory infection and disease.

Langerhans islets induce anti-tumor immunity at the expense of glycemic control and predict chemotherapy response in pancreatic cancer

This study shows that Langerhans islets in pancreatic tumors promote anti-tumor immunity but impair glycemic control, and identifies T2DM and HbA1c as predictors of chemotherapy response.

Comparative analysis of Wnt signaling-related proteins in normal, benign, malignant and metastasised human liver tumors

The paper quantifies Wnt signaling protein expression in liver tumors to identify markers distinguishing benign, malignant, and metastatic tumors.