Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis
M. Maio, J. Barros, M. Joly, Z. Vahlas, J. L. Marin Franco, M. Genoula, S. Monard, M. B. Vecchione, F. Fuentes, V. Gonzalez Polo, M. F. Quiroga, M. Vermeulen, T. P. Vu Manh, R. J. Argüello, S. Inwentarz, , L. Balboa
This study shows that elevated glycolytic metabolism in monocytes during tuberculosis impairs their differentiation into migratory dendritic cells, limiting immune response.
bioRxiv · Apr 3, 2023Immunology