Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells
J. P. Nguyen, M. Bianca, R. D. Huff, N. Tiessen, M. D. Inman, J. A. Hirota
This study tests cAMP modulation via ABCC4 and PDE-4 inhibition as an add-on therapy to VX-770 to increase CFTR activity in human airway epithelial cells.
bioRxiv · Sep 11, 2020Cell Biology