Author

N. Tiessen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. A. Hirota· 5 shared A. C. Doxey· 3 shared A. Chandiramohan· 3 shared J. A. Aguiar· 3 shared K. Ask· 3 shared S. Revill· 3 shared B. J.-M. Tremblay· 2 shared G. Cox· 2 shared

Activity by Year

2020-2020 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersImmunology

J. A. Hirota

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Author profile →

6 papers

Recent·Most cited

An Adhesive Based Fabrication Technique for Culture of Lung Airway Epithelial Cells with Applications in Microfluidics and Lung on a Chip

N. Tiessen, M. Dabaghi, Q. Cao, A. Chandiramohan, P. R. Selvaganapathy, J. Hirota

This paper introduces a cost-effective cell culture method using pressure-sensitive adhesives for growing lung airway epithelial cells on porous membranes, enabling transfer to microfluidic chips for further analysis.

bioRxiv · Nov 19, 2020 · PreprintBioengineering

Potentiation of Long-Acting β2-Agonist and Glucocorticoid Responses in Human Airway Epithelial Cells by Modulation of Intracellular cAMP

Y. Kim, V. Hou, R. D. Huff, J. A. Aguiar, S. Revill, N. Tiessen, C. Cao, M. S. Miller, M. D. Inman, K. Ask, A. C. Doxey, J. A. Hirota

This study shows that inhibiting PDE4 or ABCC4 enhances the anti-inflammatory effects of LABA/GCS in human airway epithelial cells exposed to viral stimuli.

bioRxiv · Nov 9, 2020Immunology

Development and validation of an open-source, disposable, 3D-printed in vitro environmental exposure system for Transwell culture inserts

A. Chandiramohan, M. Dabaghi, J. Aguiar, N. Tiessen, M. Stewart, Q. Cao, J. Nguyen, N. Makhdami, G. Cox, A. Doxey, J. A. Hirota

The paper develops and validates an open-source 3D-printed in vitro system to study cannabis smoke exposure on human airway epithelial cells, showing changes in morphology and cytokine expression without significant cytotoxicity.

bioRxiv · Oct 27, 2020Bioengineering

Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

J. P. Nguyen, M. Bianca, R. D. Huff, N. Tiessen, M. D. Inman, J. A. Hirota

This study tests cAMP modulation via ABCC4 and PDE-4 inhibition as an add-on therapy to VX-770 to increase CFTR activity in human airway epithelial cells.

bioRxiv · Sep 11, 2020Cell Biology

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

J. A. Aguiar, B. J.-M. Tremblay, M. J. Mansfield, O. Woody, B. Lobb, A. Banerjee, A. Chandiramohan, N. Tiessen, A. Dvorkin-Gheva, S. Revill, M. S. Miller, C. Carlsten, L. Organ, C. Joseph, A. John, , J. A. Hirota

The paper examines gene expression and protein localization of potential SARS-CoV-2 receptors in human airway epithelial cells and lung tissue, finding low ACE2 expression and confirming other candidate receptors.

bioRxiv · Apr 7, 2020Immunology

ABCF1 regulates dsDNA-induced immune responses in human airway epithelial cells

Q. T. Cao, J. A. Aguiar, B. J.-M. Tremblay, N. Abbas, N. Tiessen, S. Revill, N. Makhdami, A. Ayoub, G. Cox, K. Ask, A. C. Doxey, J. A. Hirota

This study identifies ABCF1 as a cytosolic nucleic acid sensor in human airway epithelial cells that modulates antiviral responses and interacts with TLR signaling.

bioRxiv · Feb 8, 2020Immunology