A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
L. Donker, M. J. Vliem, H. Canever, M. Gomez-Gonzalez, M. Bosch-Padros, W.-J. Pannekoek, X. Trepat, N. Borghi, M. Gloerich
The paper shows epithelial cells use a mechanical G2 checkpoint regulated by E-cadherin adhesions to control division in response to cell density changes.
bioRxiv · Nov 29, 2021Cell Biology