N. Borghi

Collective directional memory controls the range of epithelial cell migration

The paper shows that epithelial cells exhibit superdiffusive migration in tissues due to directional memory from velocity coordination and adhesion dynamics, enhancing their range compared to isolated cells.

Interactions of netrin-1 through its glycosylation sites immobilize Deleted in Colorectal Cancer (DCC) by favoring its constitutive clustering

The paper investigates how netrin-1 glycosylation sites affect DCC clustering and mobility, showing they promote constitutive nanoclusters and reduce DCC movement.

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

The paper shows epithelial cells use a mechanical G2 checkpoint regulated by E-cadherin adhesions to control division in response to cell density changes.

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signalling

The paper investigates how extracellular domains of E-cadherin influence epithelial mechanical properties through cell- and non-cell-autonomous signaling.

Actin accumulates nesprin-2 at the front of the nucleus during confined cell migration

The paper shows actin redistributes nesprin-2 giant to the front of the nucleus during migration through narrow constrictions, contributing to nuclear pulling forces.

LINC complexes are mechanotransducers that discriminate Epithelial-Mesenchymal Transition programs

This study shows LINC complexes sense mechanical tension and regulate β-catenin signaling differently during partial and complete EMT.

Chromatin Condensation Fluctuations Rather Than Steady-State Predict Chromatin Accessibility

The paper shows chromatin condensation fluctuations, not steady-state condensation, predict accessibility of acetylated histone H4 to bromodomains in live cells.

Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts