M. Butte

Augmentation of T-cell activation by oscillatory forces and engineered antigen-presenting cells

This study shows that oscillatory movement of engineered antigen-presenting cells enhances T-cell activation and expands regulatory T cells more effectively than static cultures.

Tissue mechanics controls T-cell activation and metabolism

This study shows that tissue mechanics control T-cell activation and metabolism by regulating YAP-dependent NFAT nuclear translocation, affecting T-cell responses in viral infections and autoimmune diabetes.