F. S. Majedi

Global anti-tumor immunity after localized, bioengineered Treg depletion

This paper presents a biodegradable scaffold that locally depletes Tregs and activates T cells to clear solid tumors, inducing an immunological abscopal effect on distant tumors.

Augmentation of T-cell activation by oscillatory forces and engineered antigen-presenting cells

This study shows that oscillatory movement of engineered antigen-presenting cells enhances T-cell activation and expands regulatory T cells more effectively than static cultures.

Tissue mechanics controls T-cell activation and metabolism

This study shows that tissue mechanics control T-cell activation and metabolism by regulating YAP-dependent NFAT nuclear translocation, affecting T-cell responses in viral infections and autoimmune diabetes.

T-cell activation is modulated by the 3D mechanical microenvironment

This study shows that T-cell activation increases in stiffer 3D hydrogels compared to softer ones, indicating mechanical sensing by T cells.