In colon cancer cells, fascin1 functions as a mechanosensor that transforms adherens junction mechanotransduction.
A. Esmaeilniakooshkghazi, E. Pham, S. P. George, A. Ahrorov, F. R. Villagomez, M. Byington, S. Mukhopadhyay, S. Patnaik, J. C. Conrad, M. Naik, S. Ravi, N. Tebbuttt, J. Mooi, C. M. Reehorst, J. M. Mariadason, S. Khurana
This study identifies fascin1 as a mechanosensor in colon cancer cells that modulates adherens junction plasticity, promoting tumor growth and metastasis.
bioRxiv · Jun 14, 2022 · PreprintCancer Biology