Author
S. Khurana
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2020-2023 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author links12 papers
Recent·Most cited
Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates
R. D. Malewana, V. Stalls, A. May, X. Lu, D. R. Martinez, A. Schafer, D. Li, M. Barr, L. L. Sutherland, E. Lee, R. Parks, W. E. Beck, A. Newman, K. W. Bock, M. Minai, , K. O. Saunders
Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.
bioRxiv · Dec 18, 2023 · PreprintImmunology
Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2
Y. Feng, M. Yuan, J. M. Powers, M. Hu, J. E. Munt, P. S. Arunachalam, S. R. Leist, L. Bellusci, L. E. Adams, S. Sundaramurthy, L. M. Shirreff, M. L. Mallory, T. D. Scooby, A. Moreno, D. T. OHagan, , B. Pulendran
This study identifies potent pan-sarbecovirus neutralizing antibodies from vaccinated macaques, showing broad neutralization against SARS-CoV-2 variants and related viruses.
bioRxiv · Jan 19, 2023 · PreprintImmunology
Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism
S. Luo, J. Zhang, A. J. B. Kreutzberger, A. Eaton, R. J. Edwards, C. Jing, H.-Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, , F. W. Alt
The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.
bioRxiv · Jun 26, 2022 · PreprintImmunology
In colon cancer cells, fascin1 functions as a mechanosensor that transforms adherens junction mechanotransduction.
A. Esmaeilniakooshkghazi, E. Pham, S. P. George, A. Ahrorov, F. R. Villagomez, M. Byington, S. Mukhopadhyay, S. Patnaik, J. C. Conrad, M. Naik, S. Ravi, N. Tebbuttt, J. Mooi, C. M. Reehorst, J. M. Mariadason, S. Khurana
This study identifies fascin1 as a mechanosensor in colon cancer cells that modulates adherens junction plasticity, promoting tumor growth and metastasis.
bioRxiv · Jun 14, 2022 · PreprintCancer Biology
Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine
D. Li, D. R. Martinez, A. Schäfer, H. Chen, M. Barr, L. L. Sutherland, E. Lee, R. Parks, D. Mielke, W. Edwards, A. Newman, K. W. Bock, M. Minai, B. M. Nagata, M. Gagne, , B. F. Haynes
This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.
bioRxiv · Jan 26, 2022Immunology
Histone Variant macroH2A1 Spatially and Functionally Organizes Human Papillomavirus Replication Foci in the Productive Stage of Infection
S. Khurana, T. E. Markowitz, J. Kabat, A. A. McBride
This study shows macroH2A1 spatially organizes HPV replication foci by separating replication and transcription activities in differentiated cells.
bioRxiv · Jul 27, 2021 · PreprintMicrobiology
Reduced neutralization of SARS-CoV-2 variants by convalescent plasma and hyperimmune intravenous immunoglobulins for treatment of COVID-19
J. Tang, Y. Lee, S. Ravichandran, G. Grubbs, C. Huang, C. Stauft, T. Wang, B. Golding, H. Golding, S. Khurana
This study evaluates the neutralization capacity of hyperimmune immunoglobulins and convalescent plasma against SARS-CoV-2 and its variants, finding reduced effectiveness against certain variants with hCoV-2IG showing better cross-neutralization than convalescent plasma.
bioRxiv · Mar 19, 2021Immunology
Bacterial expression and purification of functional recombinant SARS-CoV-2 spike receptor binding domain
J. Prahlad, L. Struble, W. E. Lutz, S. A. Wallin, S. Khurana, A. Schnaubelt, M. J. Broadhurst, K. Bayles, G. E. O. Borgstahl
This paper describes a bacterial method to produce functional SARS-CoV-2 spike protein receptor binding domain for diagnostic and therapeutic applications.
bioRxiv · Feb 3, 2021 · PreprintBiochemistry
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells
S. Sagar, A. K. Rathinavel, W. E. Lutz, L. R. Struble, S. Khurana, A. T. Schnaubelt, N. K. Mishra, C. Guda, M. J. Broadhurst, S. P. Reid, K. W. Bayles, G. E. O. Borgstahl, P. Radhakrishnan
This study shows bromelain reduces ACE-2 and TMPRSS2 expression and inhibits SARS-CoV-2 infection in VeroE6 cells.
bioRxiv · Sep 16, 2020 · PreprintMicrobiology
Interruption in POSTN-ITGAV axis affects lympho-hematopoiesis in mouse spleen
S. H. Mehatre, I. M. Roy, A. Biswas, D. Prit, S. Schouteden, J. Huelsken, C. M. Verfaillie, S. Khurana
This study shows that disrupting the POSTN-ITGAV axis in mice affects spleen lympho-hematopoiesis by altering HSC proliferation, differentiation, and stromal support.
bioRxiv · Aug 11, 2020Immunology
Antibody repertoire induced by SARS-CoV-2 spike protein immunogens
S. Ravichandran, E. M. Coyle, L. Klenow, J. Tang, G. Grubbs, S. Liu, T. Wang, H. Golding, S. Khurana
This study evaluates antibody responses to different SARS-CoV-2 spike protein antigens in rabbits, finding that the RBD antigen elicited higher affinity and titer neutralizing antibodies.
bioRxiv · May 12, 2020Microbiology