Complexes of tubulin oligomers and tau form an intervening network cross-bridging microtubules into bundles
P. Kohl, C. Song, B. J. Fletcher, R. L. Best, C. Tchounwou, X. G. Arceo, P. J. Chung, H. P. Miller, L. Wilson, M. C. Choi, Y. Li, S. C. Feinstein, C. R. Safinya
The paper identifies an intervening network of tubulin-tau complexes that cross-link microtubules into bundles, revealing a new role for tubulin in stabilizing MT fascicles and preventing tau leakage in neurodegeneration.
bioRxiv · Jul 18, 2022 · PreprintBiophysics