Author

C. R. Safinya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 4 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

V. M. Steffes· 5 shared K. K. Ewert· 4 shared Y. Li· 3 shared B. J. Fletcher· 2 shared K. Ewert· 2 shared L. Simon-Gracia· 2 shared T. Teesalu· 2 shared W. S. Fisher· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersBiophysics

V. M. Steffes

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Author profile →

7 papers

Recent·Most cited

Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes

V. M. Steffes, S. MacDonald, J. Crowe, M. Murali, K. K. Ewert, Y. Li, C. R. Safinya

This study shows that lipids with negative spontaneous curvature, like DOPE and GMO, reduce paclitaxel solubility in liposomes, making them unsuitable for drug delivery.

bioRxiv · Oct 18, 2023Biophysics

The Influence of Multivalent Charge and PEGylation on Shape Transitions in Fluid Lipid Assemblies: From Vesicles to Discs, Rods, and Spheres

V. M. Steffes, Z. Zhang, K. K. Ewert, C. R. Safinya

This study investigates how multivalent cationic lipid MVL5 and PEG-lipids affect the structure of fluid lipid assemblies, revealing distinct morphologies like discs, rods, and spheres.

bioRxiv · Aug 9, 2023 · PreprintBiophysics

Paclitaxel-loaded Cationic Fluid Lipid Nanodiscs and Liposomes with Brush-Conformation PEG Chains Penetrate Breast Tumors and Trigger Caspase-3 Activation

L. Simon-Gracia, P. D. Scodeller, W. S. Fisher, V. Sidorenko, V. M. Steffes, K. K. Ewert, C. R. Safinya, T. Teesalu

This study shows that increasing PEG coverage on cationic lipid nanoparticles improves their tumor penetration and proapoptotic activity when delivering paclitaxel.

ACS Applied Materials & Interfaces · Dec 15, 2022Peer-reviewedBiophysics

Complexes of tubulin oligomers and tau form an intervening network cross-bridging microtubules into bundles

P. Kohl, C. Song, B. J. Fletcher, R. L. Best, C. Tchounwou, X. G. Arceo, P. J. Chung, H. P. Miller, L. Wilson, M. C. Choi, Y. Li, S. C. Feinstein, C. R. Safinya

The paper identifies an intervening network of tubulin-tau complexes that cross-link microtubules into bundles, revealing a new role for tubulin in stabilizing MT fascicles and preventing tau leakage in neurodegeneration.

bioRxiv · Jul 18, 2022 · PreprintBiophysics

Enhanced Loading of Paclitaxel in Cationic Liposomes by Replacement of Oleoyl with Linoleoyl Lipid Tails with Benefits in Cancer Therapeutics from In Vitro Studies

Y. Zhen, K. K. Ewert, W. S. Fisher, V. M. Steffes, Y. Li, C. R. Safinya

This study shows that replacing oleoyl with linoleoyl lipid tails in cationic liposomes increases paclitaxel solubility, enhancing cancer therapeutic efficacy without increasing toxicity.

bioRxiv · Oct 12, 2020Biophysics

Competition of Charge-Mediated and Specific Binding by Peptide-Tagged Cationic Liposome-DNA Nanoparticles In Vitro and In Vivo

E. Wonder, L. Simon-Gracia, P. Scodeller, R. N. Majzoub, V. R. Kotamraju, K. Ewert, T. Teesalu, C. R. Safinya

This study investigates how peptide density and charge affect the binding and uptake of cationic liposome-DNA nanoparticles by cancer cells and evaluates their tumor selectivity in vivo.

bioRxiv · Dec 20, 2017Biophysics

Distinct Solubility and Cytotoxicity Regimes of Paclitaxel-Loaded Cationic Liposomes at Low and High Drug Content Revealed by Kinetic Phase Behavior and Cancer Cell Viability Studies

V. M. Steffes, M. M. Murali, Y. Park, B. J. Fletcher, K. Ewert, C. R. Safinya

This paper investigates the solubility and cytotoxicity of paclitaxel-loaded cationic liposomes at different drug contents, revealing nonmonotonic efficacy patterns linked to kinetic phase behavior.

bioRxiv · Jun 23, 2017Biophysics