K18-hACE2 Mice for Studies of COVID-19 Treatments and Pathogenesis Including Anosmia
S. Perlman, J. Zheng, L. Y. R. WONG, K. Li, A. K. Verma, M. E. Ortiz Bezara, C. Wohlford-Lenane, M. R. Leidinger, M. C. Kundson, D. K. Meyerholz, P. B. McCray
This study uses K18-hACE2 mice to demonstrate severe SARS-CoV-2 infection in lungs and brains, thrombosis in severe cases, and the protective effect of convalescent plasma against lethal disease, while showing anosmia occurs independently of clinical outcome.
bioRxiv · Aug 7, 2020Microbiology