Quantitative Restoration of Immune Defense in Old Animals Determined by Naive Antigen-Specific CD8 T cell Numbers
J. Uhrlaub, M. Jergovic, C. M. Bradshaw, S. Sonar, C. P. Coplen, J. Dudakov, K. O. Murray, M. C. Lanteri, M. P. Busch, M. R. M. van den Brink, J. Nikolich-Zugich
This study shows that increasing naive CD8 T cell numbers in old mice with IL-7C improves antigen-specific T cell numbers but not survival or effector immunity against WNV.
bioRxiv · Aug 9, 2021Immunology