M. P. Busch

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

Administration of vaccine-boosted COVID-19 convalescent plasma to SARS-CoV-2 infected hamsters decreases virus replication in lungs and hastens resolution of the infection despite transiently enhancing disease and lung pathology.

This study shows that vaccine-boosted convalescent plasma reduces SARS-CoV-2 replication in hamsters but temporarily worsens disease and lung pathology.

Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors

The paper identifies 423 genetic loci associated with 132 metabolites in red blood cells using a genome-wide association study of volunteer blood donors.

HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions

This study identifies epigenetic and transcriptional features in HIV-specific CD8 T cells from elite controllers that support long-lived effector functions and developmental potential.

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation

This study treats SARS-CoV-2 infected macaques with high-titer convalescent plasma, showing reduced lung inflammation without affecting virus replication.

Quantitative Restoration of Immune Defense in Old Animals Determined by Naive Antigen-Specific CD8 T cell Numbers

This study shows that increasing naive CD8 T cell numbers in old mice with IL-7C improves antigen-specific T cell numbers but not survival or effector immunity against WNV.

Distinct cellular immune signatures in acute Zika virus infection are associated withhigh or low persisting neutralizing antibody titers

The paper uses mass cytometry to identify immune cell signatures in acute ZIKV infection that predict high or low neutralizing antibody titers 6 months post-infection.

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality

This paper investigates the role of the N-terminus of band 3 in red blood cell metabolism and storage quality using genetic models and proteomic analyses, showing its impact on metabolic pathways and transfusion outcomes.

Distinct SARS-CoV-2 Antibody Reactivity Patterns in Coronavirus Convalescent Plasma Revealed by a Coronavirus Antigen Microarray

This study uses a coronavirus antigen microarray to identify distinct antibody reactivity patterns in SARS-CoV-2 convalescent plasma, showing high concordance with existing assays and revealing clusters with potential implications for treatment efficacy.

Analysis of SARS-CoV-2 Antibodies in COVID-19 Convalescent Blood using a Coronavirus Antigen Microarray

This paper validates a coronavirus antigen microarray to distinguish SARS-CoV-2 convalescent blood from pre-pandemic controls, showing improved discrimination with spike and nucleoprotein antigens.

Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

This study assesses the precision and repeatability of HIV-1 latent reservoir size measurements using QVOA across labs and storage conditions, finding assay variability and supporting frozen storage.