Author

C. P. Coplen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Nikolich-Zugich· 4 shared M. Jergovic· 4 shared J. L. Uhrlaub· 3 shared B. J. LaFleur· 2 shared M. R. M. van den Brink· 2 shared S. A. Sonar· 2 shared A. S. Sukhina· 1 shared B. A. Bixby· 1 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

J. Nikolich-Zugich

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5 papers

Recent·Most cited

T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults

M. Jergovic, M. Watanabe, R. Bhat, C. P. Coplen, S. A. Sonar, R. Wong, Y. Castaneda, L. Davidson, M. Kala, R. C. Wilson, H. L. Twigg, K. Knox, H. E. Erickson, C. C. Weinkauf, C. Bime, , J. Z. Nikolich

The paper identifies T-cell stress and reticulocyte signatures as markers of severe COVID-19 in older adults, while showing naive T-cell decline is age-related, not disease-specific.

bioRxiv · Dec 21, 2022Immunology

LIFELONG CYTOMEGALOVIRUS AND EARLY-LIFE IRRADIATION SYNERGISTICALLY POTENTIATE AGE-RELATED DEFECTS IN RESPONSE TO VACCINATION AND INFECTION

J. L. Pugh, C. P. Coplen, A. S. Sukhina, J. L. Uhrlaub, J. L. Padilla-Torres, T. Hayashi, J. Nikolich-Zugich

This study shows that lifelong cytomegalovirus and early-life irradiation together worsen age-related immune defects in response to vaccination and infection.

bioRxiv · Dec 1, 2021Immunology

The impact of murine cytomegalovirus (mCMV) route and age at infection upon virus spread, immune responses and the establishment of latency

C. P. Coplen, M. Jergovic, E. L. Terner, J. L. Uhrlaub, J. Nikolich-Zugich

This study compares the effects of infection route and age on mCMV spread, immune responses, and latency in mice, finding age-related differences in immune activation and T cell responses.

bioRxiv · Nov 29, 2021 · PreprintImmunology

Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging

S. A. Sonar, J. L. Uhrlaub, C. P. Coplen, G. D. Sempowski, J. A. Dudakov, M. R. M. van den Brink, B. J. LaFleur, M. Jergovic, J. Nikolich-Zugich

This study shows that skin-draining lymph nodes atrophy early in mice, leading to impaired immune function and reduced effector cell production in older age.

bioRxiv · Nov 22, 2021Immunology

Quantitative Restoration of Immune Defense in Old Animals Determined by Naive Antigen-Specific CD8 T cell Numbers

J. Uhrlaub, M. Jergovic, C. M. Bradshaw, S. Sonar, C. P. Coplen, J. Dudakov, K. O. Murray, M. C. Lanteri, M. P. Busch, M. R. M. van den Brink, J. Nikolich-Zugich

This study shows that increasing naive CD8 T cell numbers in old mice with IL-7C improves antigen-specific T cell numbers but not survival or effector immunity against WNV.

bioRxiv · Aug 9, 2021Immunology