M. Koenigshoff

Primary human lung fibroblasts exhibit trigger- but not disease-specific cellular senescence and impair alveolar epithelial cell progenitor function

This study shows that primary human lung fibroblasts from different disease origins exhibit similar susceptibility to senescence induction but distinct senescent programs, which impair alveolar epithelial progenitor function.

Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis

This study shows that loss of ANT1 increases fibrosis and epithelial cell senescence in IPF by causing mitochondrial dysfunction.

Single cell transcriptome mapping identifies a local innate B cell population driving local antibody production and chronic rejection after lung transplantation

The paper identifies a local innate B cell population that drives antibody production and chronic rejection in lung transplants using single-cell transcriptomics.

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

Notch1 inhibition restores alveolar epithelial differentiation, reduces surface tension, and reverses matrix deposition in lung fibrosis.