M. C. Montoya

Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates

This study identifies mefloquine derivatives as broad-spectrum antifungals effective against drug-resistant fungal isolates, with mechanisms involving mitochondrial and vacuolar disruption.

Tox_(R)CNN: Deep Learning-Based Nuclei Profiling tool For Drug Toxicity Screening

This paper develops Tox-(R)CNN models to predict drug toxicity from nuclei images, showing improved sensitivity and broader specificity compared to existing methods.