Author

A. Diez-Sanchez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H. T. Lindholm· 3 shared M. J. Oudhoff· 3 shared N. Parmar· 3 shared J. Ostrop· 2 shared A. Quilez-Alvarez· 1 shared C. Arrowsmith· 1 shared C. L. Drurey· 1 shared D. Jimenez-Carretero· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

H. T. Lindholm

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Postnatal intestinal epithelial maturation by LSD1 controls the small intestinal immune cell composition independently from the microbiota

A. Diez-Sanchez, H. T. Lindholm, P. M. Vornewald, J. Ostrop, N. Parmar, T. N. Shaw, M. Martin-Alonso, M. J. Oudhoff

This study shows that LSD1 in intestinal epithelial cells controls immune cell composition postnatally, independent of microbiota.

bioRxiv · Sep 8, 2023Immunology

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial differentiation

J. Ostrop, R. Zwiggelaar, M. T. Pedersen, F. Gerbe, K. Bösl, H. T. Lindholm, A. Diez-Sanchez, N. Parmar, S. Radetzki, J. P. von Kries, P. Jay, K. B. Jensen, C. Arrowsmith, M. J. Oudhoff

This study develops a semi-automated intestinal organoid screening method to identify epigenetic regulators of epithelial differentiation, finding that inhibiting type I PRMTs enhances differentiation and blocks adenoma growth.

bioRxiv · Jul 23, 2020Cell Biology

Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

H. T. Lindholm, N. Parmar, C. L. Drurey, J. L. Ostrop, A. Diez-Sanchez, R. Maizels, M. J. Oudhoff

The paper investigates how cytokines regulate intestinal epithelial responses through developmental pathways, showing IL-13 induces goblet cells via NOTCH signaling and uses BMP signaling as a feedback loop in tuft cell hyperplasia.

bioRxiv · Jun 19, 2020Immunology

Tox_(R)CNN: Deep Learning-Based Nuclei Profiling tool For Drug Toxicity Screening

D. Jimenez-Carretero, V. Abrishami, L. Fernandez-de-Manuel, I. Palacios, A. Quilez-Alvarez, A. Diez-Sanchez, M. A. del Pozo, M. C. Montoya

This paper develops Tox-(R)CNN models to predict drug toxicity from nuclei images, showing improved sensitivity and broader specificity compared to existing methods.

PLOS Computational Biology · Nov 30, 2018Peer-reviewedPharmacology & Toxicology