S. R. Beattie

CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms

Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo Candida albicans vascular catheter infection and ex vivo Candida auris skin colonization

This study identifies and characterizes novel keto-alkyl-pyridinium antifungal molecules with broad spectrum activity against fungi, showing efficacy in in vivo and ex vivo models of infection.

FKS1 is required for Cryptococcus neoformans fitness in vivo: application of copper-regulated gene expression to mouse models of cryptococcosis

This paper uses copper-regulated gene expression to study FKS1 in C. neoformans, showing reduced in vivo fungal burden with lower FKS1 expression.

Genetic interaction analysis reveals that Cryptococcus neoformans utilizes multiple acetyl-CoA-generating pathways during infection

This study identifies multiple acetyl-CoA-generating pathways in Cryptococcus neoformans essential for infection, showing synthetic lethality between ACL1 and ACS1 and reduced fitness in vivo.

An Alanine Aminotransferase is Required for Polysaccharide Regulation and Resistance of Aspergillus fumigatus Biofilms to Echinocandin Treatment

This study shows that alanine aminotransferase AlaA is essential for A. fumigatus biofilm formation and resistance to echinocandin antifungals, with its inhibition increasing drug susceptibility.

Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates

This study identifies mefloquine derivatives as broad-spectrum antifungals effective against drug-resistant fungal isolates, with mechanisms involving mitochondrial and vacuolar disruption.

Host carbon dioxide concentration is an independent stress for Cryptococcus neoformans that affects virulence and antifungal susceptibility

This study identifies CO2 tolerance as a virulence trait in Cryptococcus neoformans, linking it to disease severity and antifungal drug susceptibility.

Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fischeri, a close relative of the major human fungal pathogen Aspergillus fumigatus

This study compares Aspergillus fischeri and Aspergillus fumigatus to understand differences in pathogenicity, finding A. fischeri is less virulent, grows slower under stress, and has divergent secondary metabolism.